Physical and Chemical Properties

• Melting Point: 44–46 °C

• Boiling Point: 89.67 °C (rough estimate)

• Density: 0.9325

• Solubility: Slightly soluble in acetonitrile; slightly soluble in chloroform

• Physical Form: Molten solid

• Color: Light yellow to beige

Product Overview

3,4-Dimethylpyrazole is an important pyrazole heterocyclic intermediate, widely used in pharmaceuticals, agrochemicals, and functional materials. The 3,4-dimethyl substitution provides favorable electronic effects and steric configuration, making it valuable in the structural design and optimization of bioactive molecules.

Applications

△ Pharmaceutical

In medicinal chemistry research, 3,4-dimethylpyrazole is commonly used as a key structural unit or synthetic intermediate to construct compounds with defined pharmacological activity, including but not limited to:

• Plasma hormone–related inhibitors

• IAP (Inhibitor of Apoptosis Protein) inhibitors

• CRF receptor inhibitors

• MAGL inhibitors

Related derivatives are studied for applications in anticancer, antidiabetic, cardiovascular, antibacterial, and sedative drug research, primarily at the R&D and preclinical stages.

△ Agricultural and Fertilizer 

3,4-Dimethylpyrazole has a well-established and commercialized application base in agriculture. Many nitrogen fertilizer nitrification inhibitors are optimized based on this structure, the most representative being:

3,4-Dimethylpyrazole Phosphate (DMPP)

Developed by BASF (Germany), DMPP is a highly efficient, low-toxicity, and environmentally friendly nitrogen fertilizer nitrification inhibitor that has been widely adopted in large-scale agricultural applications worldwide.

Product Advantages Summary

• Mature structure with extensively validated applications

• Covers both pharmaceutical R&D and agricultural commercial use

• Strong derivative potential for active molecule optimization

• Clear industrial application pathways

• Long-term, large-scale commercialization represented by DMPP

• Aligned with modern agriculture and green chemistry trends